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While demonstrating an ability to replicate the appearance and key biological features of the composite IVD, only the composite structure with oriented AF was found to reproduce any key mechanical parameters such as integration strength or compressive stiffness

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A detailed introduction of the structure and function of BBB was given based on the mechanism of BBB, while comparing with the pathological changes of BBB in neurodegenerative diseases (NDDs), including activation of endothelial cells, the loose of tight junction and increase of BBB permeability